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Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein

Molecular chaperones are an essential part of the machinery that avoids protein aggregation and misfolding in vivo. However, understanding the molecular basis of how chaperones prevent such undesirable interactions requires the conformational changes within substrate proteins to be probed during cha...

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Hlavní autoři: Kellner, Ruth, Hofmann, Hagen, Barducci, Alessandro, Wunderlich, Bengt, Nettels, Daniel, Schuler, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169939/
https://ncbi.nlm.nih.gov/pubmed/25165400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407086111
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