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Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein

Molecular chaperones are an essential part of the machinery that avoids protein aggregation and misfolding in vivo. However, understanding the molecular basis of how chaperones prevent such undesirable interactions requires the conformational changes within substrate proteins to be probed during cha...

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Detalhes bibliográficos
Main Authors: Kellner, Ruth, Hofmann, Hagen, Barducci, Alessandro, Wunderlich, Bengt, Nettels, Daniel, Schuler, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169939/
https://ncbi.nlm.nih.gov/pubmed/25165400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407086111
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