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TADOSS: computational estimation of tandem domain swap stability

SUMMARY: Proteins with highly similar tandem domains have shown an increased propensity for misfolding and aggregation. Several molecular explanations have been put forward, such as swapping of adjacent domains, but there is a lack of computational tools to systematically analyze them. We present th...

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Publicat a:Bioinformatics
Autors principals: Lafita, Aleix, Tian, Pengfei, Best, Robert B, Bateman, Alex
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612889/
https://ncbi.nlm.nih.gov/pubmed/30500878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty974
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