Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

[Image: see text] Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Haffner, Curt D., Charnley, Adam K., Aquino, Christopher J., Casillas, Linda, Convery, Máire A., Cox, Julie A., Elban, Mark A., Goodwin, Nicole C., Gough, Peter J., Haile, Pamela A., Hughes, Terry V., Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S., Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F., Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J., Zhou, Huiqiang, Bertin, John, Marquis, Robert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862347/
https://ncbi.nlm.nih.gov/pubmed/31749904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00141
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