Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

[Image: see text] Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:ACS Med Chem Lett
المؤلفون الرئيسيون: Haffner, Curt D., Charnley, Adam K., Aquino, Christopher J., Casillas, Linda, Convery, Máire A., Cox, Julie A., Elban, Mark A., Goodwin, Nicole C., Gough, Peter J., Haile, Pamela A., Hughes, Terry V., Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S., Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F., Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J., Zhou, Huiqiang, Bertin, John, Marquis, Robert W.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2019
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862347/
https://ncbi.nlm.nih.gov/pubmed/31749904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00141
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