Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis

[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protein. The deletion of phenylalanine at position 508 o...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Scanio, Marc J. C., Searle, Xenia B., Liu, Bo, Koenig, John R., Altenbach, Robert, Gfesser, Gregory A., Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M., Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Jia, Ying, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862345/
https://ncbi.nlm.nih.gov/pubmed/31749908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00377
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