Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis

[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protein. The deletion of phenylalanine at position 508 o...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Scanio, Marc J. C., Searle, Xenia B., Liu, Bo, Koenig, John R., Altenbach, Robert, Gfesser, Gregory A., Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M., Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Jia, Ying, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862345/
https://ncbi.nlm.nih.gov/pubmed/31749908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00377
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