Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic cleavage of cellular β-NAD(+). Hence, mice lacking PARP-1 or PARP-2 show DNA perturbations ranging from altered DNA integrity to impaired DNA...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Galindo-Campos, Miguel A., Bedora-Faure, Marie, Farrés, Jordi, Lescale, Chloé, Moreno-Lama, Lucia, Martínez, Carlos, Martín-Caballero, Juan, Ampurdanés, Coral, Aparicio, Pedro, Dantzer, Françoise, Cerutti, Andrea, Deriano, Ludovic, Yélamos, José
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861126/
https://ncbi.nlm.nih.gov/pubmed/30996287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0326-5
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