PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficiency of PARP-2 in a PARP-1-deficient background show...

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Published in:Sci Rep
Main Authors: Navarro, Judith, Gozalbo-López, Beatriz, Méndez, Andrea C., Dantzer, Françoise, Schreiber, Valérie, Martínez, Carlos, Arana, David M., Farrés, Jordi, Revilla-Nuin, Beatriz, Bueno, María F., Ampurdanés, Coral, Galindo-Campos, Miguel A., Knobel, Philip A., Segura-Bayona, Sandra, Martin-Caballero, Juan, Stracker, Travis H., Aparicio, Pedro, Del Val, Margarita, Yélamos, José
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299517/
https://ncbi.nlm.nih.gov/pubmed/28181505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41962
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