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PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors
Erythropoiesis is a tightly regulated process in which multipotential hematopoietic stem cells produce mature red blood cells. Here we show that deletion of poly(ADP-ribose) polymerase-2 (PARP-2) in mice leads to chronic anemia at steady state, despite increased erythropoietin plasma levels, a pheno...
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| Publicado no: | Cell Death Differ |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4568570/ https://ncbi.nlm.nih.gov/pubmed/25501596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.202 |
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