Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Insulin analogues, mainstays in the modern treatment of diabetes mellitus, exemplify the utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the individual A and B chains were accomplished in the early 1960s, their combination to form native insulin remains ineffi...

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Bibliografiska uppgifter
I publikationen:Chemistry
Huvudupphovsmän: Weil-Ktorza, Orit, Rege, Nischay, Lansky, Shifra, Shalev, Deborah E., Shoham, Gil, Weiss, Michael A., Metanis, Norman
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861001/
https://ncbi.nlm.nih.gov/pubmed/31012517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201900892
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