Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Insulin analogues, mainstays in the modern treatment of diabetes mellitus, exemplify the utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the individual A and B chains were accomplished in the early 1960s, their combination to form native insulin remains ineffi...

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Vydáno v:Chemistry
Hlavní autoři: Weil-Ktorza, Orit, Rege, Nischay, Lansky, Shifra, Shalev, Deborah E., Shoham, Gil, Weiss, Michael A., Metanis, Norman
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861001/
https://ncbi.nlm.nih.gov/pubmed/31012517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201900892
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