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BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path

Bovine pancreatic trypsin inhibitor (BPTI) is a 58-residue protein that is stabilized by three disulfide bonds at positions 5–55, 14–38 and 30–51. Widely studied for about 50 years, BPTI represents a folding model for many disulfide-rich proteins. In the study described below, we replaced the solven...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Mousa, Reem, Lansky, Shifra, Shoham, Gil, Metanis, Norman
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982216/
https://ncbi.nlm.nih.gov/pubmed/29910933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01110a
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