β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation

BACKGROUND: Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family of proteins and its deregulation has been implicated in the malignancy of several cancer types. Dlg5 was down-regulated in hepatocellular carcinoma (HCC) and lower Dlg5 expression...

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Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Wang, Dongping, Zhang, Qi, Li, Fenfen, Wang, Chan, Yang, Changming, Yu, Hong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858669/
https://ncbi.nlm.nih.gov/pubmed/31787846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-1029-1
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