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Structural basis of temperature sensation by the TRP channel TRPV3
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergoe α-to-π transitions. Dur...
Gorde:
| Argitaratua izan da: | Nat Struct Mol Biol |
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| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858569/ https://ncbi.nlm.nih.gov/pubmed/31636415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0318-7 |
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