Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

BACKGROUND: The Pharmacokinetics of Methotrexate (MTX) has been reported to show significant inter-subject variability. MTX is metabolized by SHMT1 and transported by OATP1B1 and OATP1B3 both of which show genetic polymorphisms. The non-genetic and genetic factors may influence the pharmacokinetics...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Curr Drug Metab
Main Authors: Wang, Zhiqi, Zhang, Nan, Chen, Chaoyang, Chen, Shuqing, Xu, Junyu, Zhou, Ying, Zhao, Xia, Cui, Yimin
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857112/
https://ncbi.nlm.nih.gov/pubmed/31267867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1389200220666190701094756
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados