Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia

High-dose methotrexate (HD-MTX) is widely used in pediatric acute lymphoblastic leukemia (ALL) treatment regimens. In this study, we aimed to develop a population pharmacokinetic (PK) model of HD-MTX in Chinese pediatric patients with ALL for designing personalized dosage regimens. In total, 4,517 M...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gao, Xuan, Qian, Xiao-Wen, Zhu, Xiao-Hua, Yu, Yi, Miao, Hui, Meng, Jian-Hua, Jiang, Jun-Ye, Wang, Hong-Sheng, Zhai, Xiao-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313761/
https://ncbi.nlm.nih.gov/pubmed/34326772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.701452
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