Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

BACKGROUND: The Pharmacokinetics of Methotrexate (MTX) has been reported to show significant inter-subject variability. MTX is metabolized by SHMT1 and transported by OATP1B1 and OATP1B3 both of which show genetic polymorphisms. The non-genetic and genetic factors may influence the pharmacokinetics...

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Veröffentlicht in:Curr Drug Metab
Hauptverfasser: Wang, Zhiqi, Zhang, Nan, Chen, Chaoyang, Chen, Shuqing, Xu, Junyu, Zhou, Ying, Zhao, Xia, Cui, Yimin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Bentham Science Publishers 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857112/
https://ncbi.nlm.nih.gov/pubmed/31267867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1389200220666190701094756
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