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CURRENT INSIGHTS INTO THE MECHANISM OF MAMMALIAN IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION

Immunoglobulin Class switch recombination (CSR) is the gene rearrangement process by which B lymphocytes change the immunoglobulin (Ig) heavy chain constant region to permit a switch of Ig isotype from IgM to IgG, IgA, or IgE. At the DNA level, CSR occurs via generation and joining of DNA double str...

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Détails bibliographiques
Publié dans:Crit Rev Biochem Mol Biol
Auteurs principaux: Yu, Kefei, Lieber, Michael R.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856442/
https://ncbi.nlm.nih.gov/pubmed/31509023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10409238.2019.1659227
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