Effect of CpG Dinucleotides within IgH Switch Region Repeats on Immunoglobulin Class Switch Recombination

Immunoglobulin (Ig) heavy chains undergo class switch recombination (CSR) to change the heavy chain isotype from IgM to IgG, A or E. The switch regions are several kilobases long, repetitive, and G-rich on the nontemplate strand. They are also relatively depleted of CpG (also called CG) sites for un...

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Bibliographic Details
Published in:Mol Immunol
Main Authors: Zhang, Zheng Z., Hsieh, Chih-Lin, Okitsu, Cindy Yen, Han, Li, Yu, Kefei, Lieber, Michael R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461542/
https://ncbi.nlm.nih.gov/pubmed/25899867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.04.005
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