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Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate recognition of microbial DNA and RNA while limiting recognition of self-nucleic acids(1). Failure to properly regulate these TLRs can lead to autoimmune and autoinflammatory disease(2–6). Intracellular lo...
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| Publié dans: | Nature |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6856438/ https://ncbi.nlm.nih.gov/pubmed/31546247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1611-7 |
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