Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli

BACKGROUND: Filamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide synthase-nonribosomal peptide synthetase enzymes (PKS-NRPS; NRPS-PKS). While their domain structure suggests a common ancestor with other SM proteins, their evolutionary...

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Bibliografiske detaljer
Udgivet i:BMC Genomics
Main Authors: Theobald, Sebastian, Vesth, Tammi C., Andersen, Mikael R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854747/
https://ncbi.nlm.nih.gov/pubmed/31722662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-6114-2
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