Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies

Maternofoetal physiologically-based pharmacokinetic models integrating multi-compartmental maternal and foetal units were developed using Simbiology® to estimate prenatal drug exposure. Processes governing drug disposition were described using differential equations with key system and drug-specific...

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Veröffentlicht in:Eur J Pharm Sci
Hauptverfasser: Atoyebi, Shakir Adeyinka, Rajoli, Rajith K.R., Adejuyigbe, Ebunoluwa, Owen, Andrew, Bolaji, Oluseye, Siccardi, Marco, Olagunju, Adeniyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science B.V 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853277/
https://ncbi.nlm.nih.gov/pubmed/31518681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2019.105068
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