The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

Nutrient sensing is a critical cellular process controlling metabolism and signaling. mTOR complex 1 (mTORC1) is the primary signaling hub for nutrient sensing and, when activated, stimulates anabolic processes while decreasing autophagic flux. mTORC1 receives nutrient status signals from intracellu...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Lear, Travis B., Lockwood, Karina C., Ouyang, Yurong, Evankovich, John W., Larsen, Mads B., Lin, Bo, Liu, Yuan, Chen, Bill B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Accelerated Communications
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851335/
https://ncbi.nlm.nih.gov/pubmed/31586034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.010671
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