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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing
Nutrient sensing is a critical cellular process controlling metabolism and signaling. mTOR complex 1 (mTORC1) is the primary signaling hub for nutrient sensing and, when activated, stimulates anabolic processes while decreasing autophagic flux. mTORC1 receives nutrient status signals from intracellu...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851335/ https://ncbi.nlm.nih.gov/pubmed/31586034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.010671 |
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