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The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion

Mucin 5B (MUC5B) has an essential role in mucociliary clearance that protects the pulmonary airways. Accordingly, knowledge of MUC5B structure and its interactions with itself and other proteins is critical to better understand airway mucus biology and improve the management of lung diseases such as...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Ridley, Caroline, Lockhart-Cairns, Michael P., Collins, Richard F., Jowitt, Thomas A., Subramani, Durai B., Kesimer, Mehmet, Baldock, Clair, Thornton, David J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851316/
https://ncbi.nlm.nih.gov/pubmed/31570524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010771
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