Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers that are further packed into larger assemblies because of low pH and high Ca(2+) in the secretory granule of the mucin-producing cell. We purified the recombina...

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Vydáno v:J Biol Chem
Hlavní autoři: Trillo-Muyo, Sergio, Nilsson, Harriet E., Recktenwald, Christian V., Ermund, Anna, Ridley, Caroline, Meiss, Lauren N., Bähr, Andrea, Klymiuk, Nikolai, Wine, Jeffrey J., Koeck, Philip J. B., Thornton, David J., Hebert, Hans, Hansson, Gunnar C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900763/
https://ncbi.nlm.nih.gov/pubmed/29440393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001014
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