Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers that are further packed into larger assemblies because of low pH and high Ca(2+) in the secretory granule of the mucin-producing cell. We purified the recombina...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Trillo-Muyo, Sergio, Nilsson, Harriet E., Recktenwald, Christian V., Ermund, Anna, Ridley, Caroline, Meiss, Lauren N., Bähr, Andrea, Klymiuk, Nikolai, Wine, Jeffrey J., Koeck, Philip J. B., Thornton, David J., Hebert, Hans, Hansson, Gunnar C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900763/
https://ncbi.nlm.nih.gov/pubmed/29440393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001014
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares