Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

MUC2, the major colonic mucin, forms large polymers by N-terminal trimerization and C-terminal dimerization. Although the assembly process for MUC2 is established, it is not known how MUC2 is packed in the regulated secretory granulae of the goblet cell. When the N-terminal VWD1-D2-D′D3 domains (MUC...

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Detalhes bibliográficos
Main Authors: Ambort, Daniel, Johansson, Malin E. V., Gustafsson, Jenny K., Nilsson, Harriet E., Ermund, Anna, Johansson, Bengt R., Koeck, Philip J. B., Hebert, Hans, Hansson, Gunnar C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326483/
https://ncbi.nlm.nih.gov/pubmed/22451922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120269109
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