Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not well understood. Mice lacking functional CFTR (CftrΔ508) have no lung phenotype but show similar ileal problems to human...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gustafsson, Jenny K., Ermund, Anna, Ambort, Daniel, Johansson, Malin E.V., Nilsson, Harriet E., Thorell, Kaisa, Hebert, Hans, Sjövall, Henrik, Hansson, Gunnar C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405509/
https://ncbi.nlm.nih.gov/pubmed/22711878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120562
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