Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not well understood. Mice lacking functional CFTR (CftrΔ508) have no lung phenotype but show similar ileal problems to human...

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Detaylı Bibliyografya
Asıl Yazarlar: Gustafsson, Jenny K., Ermund, Anna, Ambort, Daniel, Johansson, Malin E.V., Nilsson, Harriet E., Thorell, Kaisa, Hebert, Hans, Sjövall, Henrik, Hansson, Gunnar C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405509/
https://ncbi.nlm.nih.gov/pubmed/22711878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120562
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