Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling system that can cause birth de...

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Foilsithe in:eLife
Main Authors: Kinnebrew, Maia, Iverson, Ellen J, Patel, Bhaven B, Pusapati, Ganesh V, Kong, Jennifer H, Johnson, Kristen A, Luchetti, Giovanni, Eckert, Kaitlyn M, McDonald, Jeffrey G, Covey, Douglas F, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2019
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850779/
https://ncbi.nlm.nih.gov/pubmed/31657721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50051
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