Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling system that can cause birth de...

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Udgivet i:eLife
Main Authors: Kinnebrew, Maia, Iverson, Ellen J, Patel, Bhaven B, Pusapati, Ganesh V, Kong, Jennifer H, Johnson, Kristen A, Luchetti, Giovanni, Eckert, Kaitlyn M, McDonald, Jeffrey G, Covey, Douglas F, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850779/
https://ncbi.nlm.nih.gov/pubmed/31657721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50051
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