GENE-50. SWI/SNF COMPLEX HETEROGENEITY RELATES WITH POLYPHENOTYPIC DIFFERENTIATION, PROGNOSIS AND IMMUNE RESPONSE IN RHABDOID TUMORS

PURPOSE: Rhabdoid tumors (RTs) arise within (Atypical Teratoid/Rhabdoid Tumor-AT/RT) or outside the brain (extraCNS-RT-eCNS-RT) and are driven mainly by inactivation of the SWI/SNF complex subunit SMARCB1. A pathognomonic hallmark of RTs is heterogeneity characterized by multilineage differentiation...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Venneti, Sriram, Panwalkar, Pooja, Pratt, Drew, Chung, Chan, Dang, Derek, Lee, Paul, Martinez, Daniel, Bayliss, Jill, Smith, Kyle, Adam, Mike, Potter, Steve, Northcott, Paul, Mascarenhas, Leo, Shows, Jared, Pawel, Bruce, Margol, Ashley, Huang, Annie, Judkins, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Genetics and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847965/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.452
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