PDTM-41. INHIBITION OF DNA DOUBLE STRAND BREAK REPAIR PATHWAYS AS A PROMISING THERAPEUTIC TARGET IN DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

New approaches to the treatment of diffuse intrinsic pontine gliomas (DIPGs) are desperately needed. DNA damage response is essential for cells to maintain genome integrity as DNA is damaged by both endogenous and exogenous stressors. Many cancer cells exhibit hyper-dependency on specific DNA repair...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Pal, Sharmistha, Bian, Jie, Price, Brendan, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Pediatric Tumors
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847822/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.816
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