PDTM-41. INHIBITION OF DNA DOUBLE STRAND BREAK REPAIR PATHWAYS AS A PROMISING THERAPEUTIC TARGET IN DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

New approaches to the treatment of diffuse intrinsic pontine gliomas (DIPGs) are desperately needed. DNA damage response is essential for cells to maintain genome integrity as DNA is damaged by both endogenous and exogenous stressors. Many cancer cells exhibit hyper-dependency on specific DNA repair...

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Vydáno v:Neuro Oncol
Hlavní autoři: Pal, Sharmistha, Bian, Jie, Price, Brendan, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Pediatric Tumors
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847822/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.816
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