DRES-02. PARYLATION OF MGMT BY PARP IS REQUIRED FOR MGMT MEDIATED TEMOZOLOMIDE-INDUCED O(6)-METHYLGUANINE REPAIR: A NOVEL MECHANISM OF MGMT ACTION

Temozolomide (TMZ) is the standard chemotherapy for malignant gliomas (MG), and resistance to this drug is mediated by the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Epigenetic silencing of the MGMT gene by promoter methylation in about 40% patients is associated with loss o...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Wu, Shaofang, Gao, Feng, Koul, Dimpy, Yung, Alfred
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Drug Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847811/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.290
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