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DRES-06. PREVENTING THE EMERGENCE OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA BY PARP-1 INHIBITION
The DNA alkylating agent temozolomide (TMZ) is active against the subset of glioblastomas (GBMs) in which the O6-methylguanine DNA methyltransferase (MGMT) gene is silenced by promoter methylation. However, despite their initial sensitivity, virtually all MGMT-methylated tumors acquire drug resistan...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216424/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.313 |
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