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DRES-06. PREVENTING THE EMERGENCE OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA BY PARP-1 INHIBITION
The DNA alkylating agent temozolomide (TMZ) is active against the subset of glioblastomas (GBMs) in which the O6-methylguanine DNA methyltransferase (MGMT) gene is silenced by promoter methylation. However, despite their initial sensitivity, virtually all MGMT-methylated tumors acquire drug resistan...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Neuro Oncol |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216424/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.313 |
| Tagiau: |
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