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DRES-16. PARP INHIBITORS RESTORE TEMOZOLOMIDE SENSITIVITY IN MSH6-DEFICIENT TEMOZOLOMIDE-RESISTANT GLIOMA MODELS
INTRODUCTION: Mismatch repair (MMR) deficiency through MSH6 inactivation has been identified in approximately 30% of recurrent gliomas. This MMR deficiency represents a key molecular mechanism of acquired resistance to the alkylating chemotherapeutic agent temozolomide (TMZ). In addition, it is know...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692025/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.274 |
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