EXTH-60. PLK1 INHIBITOR TARGETS MISMATCH REPAIR DEFICIENT TEMOZOLOMIDE RESISTANT GLIOMA

BACKGROUND: Mismatch repair (MMR) deficiency through MSH6 alteration has been identified in approximately 30% of recurrent high-grade gliomas, and represents a key molecular mechanism that underlies the development of acquired resistance to the alkylating agent temozolomide (TMZ). Additionally, glio...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Higuchi, Fumi, Cahill, Daniel, Wakimoto, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692088/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.352
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