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EXTH-60. PLK1 INHIBITOR TARGETS MISMATCH REPAIR DEFICIENT TEMOZOLOMIDE RESISTANT GLIOMA
BACKGROUND: Mismatch repair (MMR) deficiency through MSH6 alteration has been identified in approximately 30% of recurrent high-grade gliomas, and represents a key molecular mechanism that underlies the development of acquired resistance to the alkylating agent temozolomide (TMZ). Additionally, glio...
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| Veröffentlicht in: | Neuro Oncol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692088/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.352 |
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