DRES-05. PREDICTORS OF SENSITIVITY TO COMBINED TEMOZOLOMIDE AND PARP INHIBITOR IN GLIOMA

Agents targeting the PARP enzyme family are under active development for the treatment of gliomas. PARP inhibitors (PARPi) can enhance the effect of temozolomide (TMZ) in IDH wild-type glioblastomas, and in addition recent studies have shown that PARP inhibitors can be selectively lethal in IDH1 mut...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Nagashima, Hiroaki, Higuchi, Fumi, Lee, Christine, Rafferty, Seamus, Miller, Julie, Wakimoto, Hiroaki, Cahill, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Drug Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847530/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.293
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