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DRES-03. INHIBITION OF HOMOLOGOUS RECOMBINATION RESENSITIZES TEMOZOLOMIDE-RESISTANT GLIOMA CELLS TO TEMOZOLOMIDE
TMZ is a DNA-methylating agent. TMZ-induced O6-methylguanine adducts, in the absence of repair by O6-methylguanine DNA methyltransferase (MGMT), mispair with thymine during the next DNA replication cycle, leading to futile DNA mismatch repair (MMR) by the MMR system, formation of double strand break...
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| Published in: | Neuro Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692313/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.261 |
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