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P08.45 Inhibition of homologous recombination resensitizes temozolomide-resistant glioma cells to temozolomide
Introduction: TMZ is a DNA-methylating agent. TMZ-induced O6-methylguanine adducts, in the absence of repair by O6-methylguanine DNA methyltransferase (MGMT), mispair with thymine during the next DNA replication cycle, leading to futile DNA mismatch repair by the mismatch repair system, formation of...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464031/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.234 |
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