DDRE-05. DECREASED EXPRESSION OF DNA DAMAGE RESPONSE PATHWAYS CORRELATES WITH SYNERGISTIC ACTIVITY OF TEMOZOLOMIDE WITH ATR INHIBITORS IN GLIOBLASTOMA

The lack of knowledge about the relationship between tumor genotypes and therapeutic responses remains one of the most important gaps in enabling the development of effective targeted cancer therapies. Increasing evidence supports the notion that DNA damage response (DDR) signaling plays an importan...

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Publicat a:Neuro Oncol
Autors principals: Wu, Shaofang, Li, Xiaolong, Singh, Sanjay, Koul, Dimpy, Yung, W K Alfred
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Drug Discovery, Drug Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651512/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.250
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