STEM-17. LOW GRADE ASTROCYTOMA MUTATIONS COOPERATE TO DISRUPT SOX2 GENOMIC ARCHITECTURE AND BLOCK DIFFERENTIATION VIA PREVIOUSLY UNIDENTIFIED ENHANCER ELEMENTS

Neomorphic mutations in isocitrate dehydrogenase I (IDH1) result in the formation of the oncometabolite 2-hydroxyglutarate (2HG) in a significant subset of gliomas and other tumors including acute myeloid leukemias. Preclinical evidence suggests that gliomas harboring IDH1 mutations undergo widespre...

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Vydáno v:Neuro Oncol
Hlavní autoři: Bready, Devin, Modrek, Aram, Guerrera, Adler, Frenster, Joshua, Skok, Jane, Placantonakis, Dimitris
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847802/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.990
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