Low-grade astrocytoma mutations in IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2

Low-grade astrocytomas (LGA) carry neomorphic mutations in Isocitrate Dehydrogenase (IDH), concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA and ATRX shRNA in human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased in...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Rep
Autors principals: Modrek, Aram S., Golub, Danielle, Khan, Themasap, Bready, Devin, Prado, Jod, Bowman, Christopher, Deng, Jingjing, Zhang, Guoan, Rocha, Pedro P., Raviram, Ramya, Lazaris, Charalampos, Stafford, James M., LeRoy, Gary, Kader, Michael, Dhaliwal, Joravar, Bayin, N. Sumru, Frenster, Joshua D., Serrano, Jonathan, Chiriboga, Luis, Baitalmal, Rabaa, Nanjangud, Gouri, Chi, Andrew S., Golfinos, John G., Wang, Jing, Karajannis, Matthias A., Bonneau, Richard A., Reinberg, Danny, Tsirigos, Aristotelis, Zagzag, David, Snuderl, Matija, Skok, Jane A., Neubert, Thomas A., Placantonakis, Dimitris G.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687844/
https://ncbi.nlm.nih.gov/pubmed/29091765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.009
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars