Low-grade astrocytoma mutations in IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2

Low-grade astrocytomas (LGA) carry neomorphic mutations in Isocitrate Dehydrogenase (IDH), concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA and ATRX shRNA in human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased in...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Modrek, Aram S., Golub, Danielle, Khan, Themasap, Bready, Devin, Prado, Jod, Bowman, Christopher, Deng, Jingjing, Zhang, Guoan, Rocha, Pedro P., Raviram, Ramya, Lazaris, Charalampos, Stafford, James M., LeRoy, Gary, Kader, Michael, Dhaliwal, Joravar, Bayin, N. Sumru, Frenster, Joshua D., Serrano, Jonathan, Chiriboga, Luis, Baitalmal, Rabaa, Nanjangud, Gouri, Chi, Andrew S., Golfinos, John G., Wang, Jing, Karajannis, Matthias A., Bonneau, Richard A., Reinberg, Danny, Tsirigos, Aristotelis, Zagzag, David, Snuderl, Matija, Skok, Jane A., Neubert, Thomas A., Placantonakis, Dimitris G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687844/
https://ncbi.nlm.nih.gov/pubmed/29091765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.009
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