Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor()()

High-grade glioma (HGG), a deadly primary brain malignancy, manifests radioresistance mediated by cell-intrinsic and microenvironmental mechanisms. High levels of the cytokine transforming growth factor-β (TGF-β) in HGG promote radioresistance by enforcing an effective DNA damage response and suppor...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Bayin, N. Sumru, Ma, Lin, Thomas, Cheddhi, Baitalmal, Rabaa, Sure, Akhila, Fansiwala, Kush, Bustoros, Mark, Golfinos, John G., Pacione, Donato, Snuderl, Matija, Zagzag, David, Barcellos-Hoff, Mary Helen, Placantonakis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2016
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156509/
https://ncbi.nlm.nih.gov/pubmed/27978994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.08.008
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