LGG-11. LOW-GRADE ASTROCYTOMA CORE MUTATIONS IN IDH1, P53 AND ATRX COOPERATE TO BLOCK DIFFERENTIATION OF HUMAN NEURAL STEM CELLS VIA EPIGENETIC REPRESSION OF SOX2

To model low-grade astrocytoma (LGA) formation, we introduced R132H IDH1, P53 shRNA and ATRX shRNA in human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased invasiveness in vivo and led to an epigenetic and transcriptional profile resembling IDH1-mutant human LGA...

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Publicado no:Neuro Oncol
Main Authors: Modrek, Aram, Golub, Danielle, Khan, Themasap, Prado, Jod, Bowman, Christopher, Deng, Jingjing, Zhang, Guoan, Rocha, Pedro, Raviram, Ramya, Lazaris, Harris, Kader, Michael, Dhaliwal, Joravar, Chi, Andrew, Golfinos, John, Tsirigos, Aristotelis, Zagzag, David, Snuderl, Matija, Skok, Jane, Neubert, Thomas, Placantonakis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475103/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.144
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