CBMT-10. MUTANT ISOCITRATE DEHYDROGENASE 1 INHIBITION INDUCES A UNIQUE MRS-DETECTABLE METABOLIC SIGNATURE IN LOW-GRADE GLIOMAS

Mutations in isocitrate dehydrogenase 1/2 (IDHmut) are reported in 70–90% of low-grade gliomas and secondary glioblastomas. IDHmut catalyzes the reduction of a-ketoglutarate (a-KG) to 2-hydroxyglutarate (2-HG), an oncometabolite that drives tumorigenesis. Inhibition of IDHmut is therefore a rapidly...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Molloy, Abigail, Lakhani, Aliya, Najac, Chloé, Subramani, Elavarasan, Marie Gillespie, Anne, Pieper, Russell O, Viswanath, Pavithra, Ronen, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Biology and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847645/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.132
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