GENE-34. THERAPEUTICALLY TARGETING EPIGENOMIC AND TRANSCRIPTIONAL DYSFUNCTION IN ATRX-DEFICIENT GLIOMA

Diffusely infiltrating gliomas feature loss-of-function mutations in the chromatin remodeler gene ATRX as defining molecular alterations delineating major adult and pediatric disease subtypes. We recently reported that Atrx deficiency drives glioma-relevant phenotypes, such as increased motility and...

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Publicat a:Neuro Oncol
Autors principals: Danussi, Carla, Singh, Anand, Pinnamaneni, Pavan, Fisher, Grant, Picketts, David, Kannan, Kasthuri, Rao, Arvind, Rai, Kunal, Huse, Jason
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Genetics and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847519/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.436
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